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Urothelial carcinoma of low malignant potential. These cell found in a voided urine are characterized by small, uniform appearing cells with a loss of polarity or cell to cell orientation. The nuclei are round with evenly distributed chromatin. Note the loss of cytoplasm. Papanicolaou stain. 400X magnification.
Urothelial carcinoma of high malignant potential. These cells found in a voided urine specimen demonstrate easily recognized criteria for malignancy. The cells are enlarged with high nuclear to cytoplasmic ratios, irregular nuclear membranes and nucleoli. Papanicolaou stain. 1000X magnification.
Urothelial carcinoma in situ. Most of the cells appear singly or in small groups. Papanicolaou stain. 400X magnification.
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